Larvicidal effects of fungal meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and yellow fever
Autor(es): Geris, Regina; Rodrigues-Fo, Edson; da Silva, Heloisa Helena Garcia; da Silva, Ionizete Garcia
Resumo: The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. ne aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1-7, previously obtained fungal secondary metabolites from Penicillium sp., against the third-instar larvae of A. aegypti. The lethal concentrations (LC50 and LC90) of 1-7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC50 value of 2.9 ppm, making it an attractive natural insecticide.
Palavras-Chave: Rio-De-Janeiro; Melia-Azedarach; Penicillium Sp; Natural-Products; Resistance; Brazil; Organophosphates; Municipalities; Endophyte; State
Imprenta: Chemistry & Biodiversity, v. 5, n. 2, p. 341-345, 2008
Identificador do objeto digital: 10.1002/cbdv.200890032
Descritores: Aedes aegypti - Public health
Data de publicação: 2008
