Autor(es): Nguyet Minh Nguyen; Duong Thi Hue Kien; Trung Vu Tuan; Nguyen Than Ha Quyen; Tran, Chau N. B.; Long Vo Thi; Dui Le Thi; Hoa Lan Nguyen; Farrar, Jeremy J.; Holmes, Edward C.; Rabaa, Maia A.; Bryant, Juliet E.; Truong Thanh Nguyen; Huong Thi Cam Nguyen; Lan Thi Hong Nguyen; Mai Phuong Pham; Hung The Nguyen; Tai Thi Hue Luong; Wills, Bridget; Chau Van Vinh Nguyen; Wolbers, Marcel; Simmons, Cameron P.

Resumo: Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each ofDENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that Vaccines or drugs must inhibit to prevent DENV transmission.

Palavras-Chave: Infectious Disease; Virology; Entomology

Imprenta: Proceedings of The National Academy of Sciences of The United States of America, v. 110, n. 22, p. 9072-9077, 2013

Identificador do objeto digital: 10.1073/pnas.1303395110

Descritores: Aedes aegypti - Infectious diseases ; Aedes aegypti - Epidemiology ; Aedes aegypti - Public health

Data de publicação: 2013

INDICADORES

ACESSO