Two genes encoding midgut-specific maltase-like polypeptides from Anopheles gambiae
Autor(es): Zheng, L. B.; Whang, L. H. S.; Kumar, V.; Kafatos, F. C.
Resumo: Full-length cDNA clones of two genes have been isolated from the African malaria vector mosquito, Anopheles gambiae. These genes, designated Agm1 and Agm2, encode maltase-like polypeptides of 498 and 599 residues, respectively. Deduced amino acid sequences contain a putative signal peptide sequence and four potential glycosylation sites. Agm1 and Agm2 show highest similarities to the Mall gene from Aedes aegypti and three clustered maltase genes from Drosophila melanogaster. Both genes are located at position 46D, in the terminal division of the left arm of the third chromosome. Agm2 has very strict tissue and temporal specificity, being expressed exclusively in the adult midgut. The specificity of Agml is similar but appears slightly broader; transcripts of this gene are detected at a low level in the pupae, and occasionally in the adult carcass after removal of the midgut. (C) 1995 Academic Press, Inc.
Palavras-Chave: Anopheles gambiae; Mosquito; Malaria; Maltase; Alpha-glucosidase
Imprenta: Experimental Parasitology, v. 81, n. 3, p. 272-283, 1995
Identificador do objeto digital: 10.1006/expr.1995.1118
Descritores: Aedes aegypti - Genome
Data de publicação: 1995
