Perspectives in the control of infectious diseases by transgenic mosquitoes in the post-genomic era - A Review
Autor(es): Speranca, Marcia Aparecida; Capurro, Margareth Lara
Resumo: Arthropod-borne diseases caused by a variety of microorganisms such as dengue virus and malaria parasites afflict billions of people worldwide imposing major economic and social burdens. Despite many efforts, vaccines against diseases transmitted by mosquitoes, with the exception of yellow fever, are not available. Control of such infectious pathogens is mainly performed by vector management and treatment of affected individuals with drugs. However, the numbers of insecticide-resistant insects and drug-resistant parasites are increasing. Therefore, inspired in recent years by a lot of new data produced by genomics and post-genomics research, several scientific groups have been working on different strategies to control infectious arthropod-borne diseases. This review focuses on recent advances and perspectives towards construction of transgenic mosquitoes refractory to malaria parasites and dengue virus transmission.
Palavras-Chave: Transgenic mosquitoes; Post genomic; Effectors molecules; Malaria; Dengue virus; Aedes aegypti; Anopheles
Imprenta: Memorias do Instituto Oswaldo Cruz, v. 102, n. 4, p. 425-433, 2007
Identificador do objeto digital: 10.1590/S0074-02762007005000054
Descritores: Aedes aegypti - Genome ; Aedes aegypti - RNA ; Aedes aegypti - Infectious diseases ; Aedes aegypti - Dengue
Data de publicação: 2007
