Dendritic cell apoptosis and the pathogenesis of dengue
Autor(es): Martins, Sharon de T.; Silveira, Guilherme F.; Alves, Lysangela R.; Duarte dos Santos, Claudia Nunes; Bordignon, Juliano
Resumo: Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.
Palavras-Chave: Dendritic cell; Apoptosis; Dengue virus
Imprenta: Viruses-Basel, v. 4, n. 11, p. 2736-2753, 2012
Identificador do objeto digital: 10.3390/v4112736
Descritores: Aedes aegypti - Cell ; Aedes aegypti - Immune response ; Aedes aegypti - Molecular structure ; Aedes aegypti - Pathogenesis ; Aedes aegypti - RNA ; Aedes aegypti - T lymphocytes ; Aedes aegypti - Immunology ; Aedes aegypti - Immunopathology ; Aedes aegypti - Viral infections ; Aedes aegypti - Dengue
Data de publicação: 2012
