Guillain–Barré Syndrome associated with Zika virus infection in Colombia

Capa:Guillain–Barré Syndrome associated with Zika virus infection in Colombia

Autor(es): Parra, Beatriz ; Lizarazo, Jairo ; Jiménez-Arango, Jorge A. ; Zea-Vera, Andrés F. ; González-Manrique, Guillermo ; Vargas, José ; Angarita, Jorge A. ; Zuñiga, Gonzalo ; Lopez-Gonzalez, Reydmar; Beltran ; Cindy L. ; Rizcala, Karen H. ; Morales, Maria T. ; Pacheco, Oscar ; Ospina, Martha L. Ospina ; Kumae, Anupama Kumar ; Cornblath, David R. ; Muñoz, Laura S. ; Osorio, Lyda ; Barreras, Paula ; Pardo, Carlos A.


Resumo: Zika virus (ZIKV), a mosquito-borne RNA flavivirus, has caused a major outbreak in the Americas that began in 2014.1 ZIKV infection manifests as a self-limited febrile syndrome associated with rash, conjunctivitis, and arthralgias.2-4 In 2013 and 2014, an increase in the number of cases of the Guillain–Barré syndrome was observed during an outbreak of ZIKV infection in French Polynesia.5,6 Recently, clusters of the Guillain–Barré syndrome and microcephaly have been spatially and temporally related to the current outbreak of ZIKV infection in the Americas.7 In Colombia, the government reported the first autochthonous case of ZIKV infection in October 2015.8 In December 2015, the Colombian Instituto Nacional de Salud (INS) documented an unusual number of cases of the Guillain–Barré syndrome in the Caribbean and the northeastern regions of Colombia. By January 2016, the outbreak of ZIKV infection had spread to most regions of Colombia. Concomitantly, an increase in the number of neuroinflammatory disorders was reported.7 Here, we describe an observational clinical and virologic study of the Guillain–Barré syndrome cases that were evaluated in the context of the ZIKV outbreak in Colombia, which further supports the association between ZIKV infection and the Guillain–Barré syndrome — in particular, the acute inflammatory demyelinating polyneuropathy (AIDP) form of the syndrome


Imprenta: The New England Journal os Medicine, v. 375, p. 1513-1523, 2016


Identificador do objeto digital: 10.1056/NEJMoa1605564


Descritores: ZIKV - Infectious diseases ; ZIKV - Inflammation ; ZIKV - Flaviviridae ; Guillain-Barre Syndrome - virus


Data de publicação: 2016