Pyrethroid-resistance and presence of two knockdown resistance (kdr) mutations, F1534C and a novel mutation T1520I, in Indian Aedes aegypti
Autor(es): Kushwah, Raja Babu S.; Dykes, Cherry L.; Kapoor, Neera; Adak, Tridibes; Singh, Om P.
Resumo: Dengue and chikungunya are the two important human arboviral infections in India transmitted mainly by Aedes aegypti. In absence of any specific drug or vaccine for these infections, vector control and personal protection are the only control options available. The success of insecticide-based vector control heavily relies upon the knowledge of the status of insecticide resistance in vector populations and the underlying mechanisms of insecticide resistance, especially in the presence of cross-resistance. Knockdown resistance (kdr) is one of the mechanisms of resistance that confers cross-resistance to DDT and pyrethroids. Currently, pyrethroids are the only insecticide class recommended for use in long-lasting insecticide nets (LLIN) and have proven superior to all other insecticides used in vector control programme, due to low mammalian toxicity, low residual activity in nature and rapid knockdown action. The present study was undertaken to determine the susceptibility status of Ae. aegypti against DDT and pyrethroids, and identification of kdr mutations. Though the presence of kdr mutations in Ae. aegypti has been reported in many countries, such a report is not available from India. This study for the first time reports the presence of two kdr mutations, F1534C and a novel mutation T1520I, in an Indian Ae. aegypti population.
Palavras-Chave: Insecticides; Mutations; DDT; Pest control; Toxicity; Hosts; Aquatic insects; Public health; Disease transmission; Dengue; Vectors; Vaccines; Infection; Pyrethroids; Cross-resistance; Mutation; Nets; Aedes aegypti
Imprenta: Plos Neglected Tropical Diseases, v. 9, n. 1, 2015.
Descritores: Aedes aegypti - Transmission ; Aedes aegypti - Vaccine ; Aedes aegypti - Dengue ; Aedes aegypti - Public health
Data de publicação: 2015
