Autor(es): Pinto, Ana Cristina Silva; Nogueira, Karla Lagos; Chaves, Francisco Celio Maia; Silva, Luis Vilmar Souza da; Tadei, Wanderli Pedro; Pohlit, Adrian Martin

Resumo: Phenylpropanoid dillapiol (1) isolated from the essential oil in leaves of Piper aduncum L. and thirteen semi-synthetic, C3 side-chain modified dillapiol derivatives 2-14 were evaluated for lethality against hemorrhagic dengue fever mosquito vector Aedes aegypti L.. First, adult female mosquitoes were exposed to these substances in a contact bioassay carried out in glass bottles at a single surface density (0.57 mu g/cm2). Then, median lethal concentrations (LC50) and LC90 were determined for active compounds. It was found that the structure of the C3 side chain was important for the toxic effects of these substances against A. aegypti adult females. Isodillapiol (2) and methyl, propyl and butyl 1-(2,3-dimethoxy-4,5-methylenedioxy phenyl)propan-2-yl ethers (3, 5 and 6, respectively) all exhibited greater mosquitocidal activity than dillapiol (1). The order of molar per surface area of mosquitocidal activities was isodillapiol (2) > butyl ether 6 > methyl ether 3 > propyl ether 5 > dillapiol (1). The potential of dillapiol and derivatives as A. aegypti mosquitocides was discussed.

Palavras-Chave: Mosquitoes; Insecticides; Chemical compounds; Organic chemicals

Imprenta: Journal of Mosquito Research, v. 2, n. 1, 2012.

Descritores: Aedes aegypti - Dengue ; Aedes aegypti - Public health

Data de publicação: 2012

INDICADORES

ACESSO