Autor(es): Bezerra-Silva, Patricia C.; Santos, Jefferson C.; Santos, Geanne K. N.; Dutra, Kamilla A.; Santana, Andrea L. B. D.; Maranhao, Claudia A.; Nascimento, Marcia S.; Navarro, Daniela M. A. F.; Bieber, Lothar W.

Resumo: The larvicidal activities of extracts of three hardwood species (Hymenaea stigonorcapa, Anadenanthera colubrina and Bowdichia virgilioides) against 4th instar larvae of Aedes aegypti were evaluated using WHO guidelines. Extracts of H. stignocarpa and A. colubrina showed weak activity. The highest larvicidal effect was obtained with the cyclohexane extract of the heartwood of B. virgilioides, which caused 100% mortality at concentrations at 50 and 100 mu g/mL. Fraction toluene/EtOAc (8:2) from this extract showed larvicidal activity (LC50 = 34.90 +/- 1.27 mu g/mL). A mixture of two compounds identified as medicarpin and maackiain exhibited a very good larvicidal activity (sub-fraction 2, LC50 = 17.5 +/- 1.87 mu g/mL) and maackiain showed to be a strong larvicidal compound (LC50 = 21.95 +/- 1.34 mu g/mL). This result can be of value in the search for new natural larvicidal compounds from other hardwood plant extracts and presents the first report of B. virgilioides being used to control a mosquito vector. (C) 2015 Elsevier Inc. All rights reserved.

Palavras-Chave: Hardwood; Maackiain; Medicarpin; Bowdichia virgilioides; Aedes aegypti

Imprenta: Experimental Parasitology, v. 153, n. , p. 160-164, 2015

Identificador do objeto digital: 10.1016/j.exppara.2015.03.018

Descritores: Aedes aegypti - Larvicide ; Aedes aegypti - Public health

Data de publicação: 2015

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