Autor(es)Lima, Estelita Pereira; Fonseca Goulart, Marilia Oliveira; Rolim Neto, Modesto Leite

ResumoThe role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 mu M). The best result in the series was obtained with the addition of verapamil (40 mu M), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated.

Palavras-ChaveAedes aegypti; ABC transporters; Resistance mechanisms

ImprentaMemorias do Instituto Oswaldo Cruz, v. 109, n. 7, p. 964-966, 2014

DescritoresAedes aegypti - Biochemistry ; Aedes aegypti - Public health

Data de Publicação:2014