Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti
Autor(es): Lima, Estelita Pereira; Fonseca Goulart, Marilia Oliveira; Rolim Neto, Modesto Leite
Resumo: The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 mu M). The best result in the series was obtained with the addition of verapamil (40 mu M), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated.
Palavras-Chave: Aedes aegypti; ABC transporters; Resistance mechanisms
Imprenta: Memorias do Instituto Oswaldo Cruz, v. 109, n. 7, p. 964-966, 2014
Identificador do objeto digital: 10.1590/0074-0276140164
Descritores: Aedes aegypti - Biochemistry ; Aedes aegypti - Public health
Data de publicação: 2014
