A high-throughput screening method to identify potential pesticides for mosquito control
Autor(es): Pridgeon, Julia W.; Becnel, James J.; Clark, Gary C.; Linthicum, Kenneth J.
Resumo: Mosquitoes that transmit human diseases are of major importance to the international public health community. Pesticides remain a major component of integrated programs to control these medically important species. However, very few types of pesticides are currently registered for mosquito control. A high-throughput screening method using first-instar larvae of Aedes aegypti was created and evaluated in our laboratory to quickly screen large numbers of chemicals for activity against mosquitoes. LC(50) values of a representative group of compounds were determined using this high-throughput screening method and compared with LD(50) values determined by topical application against female adults of Ae. aegypti. Our results show that this high-throughput screening method is suitable for screening large numbers of candidate chemicals quickly to identify effective compounds.
Palavras-Chave: High-throughput screen;ÿPesticides;ÿMosquito control
Imprenta: Journal of Medical Entomology, v. 46, n. 2, p. 335-341, 2009
Identificador do objeto digital: 10.1603/033.046.0219
Descritores: Aedes aegypti - Public health
Data de publicação: 2009
