Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health
Autor(es): Vasilakis, Nikos; Cardosa, Jane; Hanley, Kathryn A; Holmes, Edward C; Weaver, Scott C
Resumo: The four dengue virus (DENV) serotypes that circulate among humans emerged independently from ancestral sylvatic progenitors that were present in non-human primates, following the establishment of human populations that were large and dense enough to support continuous inter-human transmission by mosquitoes. This ancestral sylvatic-DENV transmission cycle still exists and is maintained in non-human primates and Aedes mosquitoes in the forests of Southeast Asia and West Africa. Here, we provide an overview of the ecology and molecular evolution of sylvatic DENV and its potential for adaptation to human transmission. We also emphasize how the study of sylvatic DENV will improve our ability to understand, predict and, ideally, avert further DENV emergence.
Palavras-Chave: Aedes - Virology, Animals, Dengue - Virology, Dengue virus - Physiology, Ecosystem, Humans, Insect vectors - Virology, Primates - Virology
Imprenta: Nature Reviews. Microbiology, v. 9, n. 7, p. 532-541, 2011.
Descritores: Zika virus - Antigenic variation ; Zika virus - Arbovirus ; Zika virus - Cell ; Zika virus - Flaviviridae ; Zika virus - Genome ; Zika virus - Molecular structure ; Zika virus - Pathogenesis ; Zika virus - DNA ; Zika virus - RNA ; Zika virus - Protein synthesis ; Zika virus - Proteins ; Zika virus - Antibodies ; Zika virus - Infectious diseases ; Zika virus - Viral infections ; Zika virus - Molecular methods ; Zika virus - PCR detection ; Zika virus - RNA virus ; Zika virus - RT-PCR ; Zika virus - Serological diagnosis ; Zika virus - Molecular screening ; Zika virus - Transmission ; Zika virus - Vaccine ; Zika virus - Chikungunya Fever ; Zika virus - Dengue ; Zika virus - Epidemiology ; Zika virus - Head size ; Zika virus - Public health
Data de publicação: 2011
