In vivo behavior of a Sindbis virus mutant isolated from persistently infected Aedes aegypti cell cultures.

Autor(es): Peleg J

Resumo: A mutant of the Sindbis virus SV-S was found to interfere with the regular course of infection by the wild strain of the virus SV-W in A. aegypti mosquitoes and in suckling mice. In mosquitoes, this result was manifested by a reduced titer of SV-W in the presence of SV-S and by a failure of the mosquitoes to transmit SV-W. In the brains of suckling mice, in the presence of SV-S, the growth of sc inoculated SV-W was suppressed, and as a result, the usually lethal course of infection by this virus was converted into a nonlethal one.

Imprenta: Annals of the New York Academy of Sciences, v. 266, n. 204, p. 213, 1975

Identificador do objeto digital:

Descritores: Aedes aegypti - Arbovirus ; Aedes aegypti - Cell ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Viral infections ; Aedes aegypti - Virus ; Aedes aegypti - Public health

Data de publicação: 1975