Experimental transmission of Mayaro virus by Aedes aegypti.

Autor(es): Long Kanya C; Ziegler Sarah A; Thangamani Saravanan; Hausser Nicole L; Kochel Tadeusz J; Higgs Stephen; Tesh Robert B

Resumo: Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae. aegypti ranged from 0% (0/31) to 84% (31/37), with blood meal virus titers between 3.4 log(10) and 7.3 log(10) plaque-forming units (PFU)/mL. Transmission of MAYV by 70% (21/30) of infected mosquitoes was shown by saliva collection and exposure to suckling mice. Amount of viral RNA in febrile humans, determined by real-time polymerase chain reaction, ranged from 2.7 to 5.3 log(10) PFU equivalents/mL. Oral susceptibility of Ae. aegypti to MAYV at titers encountered in viremic humans may limit opportunities to initiate an urban cycle; however, transmission of MAYV by Ae. aegypti shows the vector competence of this species and suggests potential for urban transmission.

Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 85, n. 4, p. 750-757, 2011

Identificador do objeto digital: 10.4269/ajtmh.2011.11-0359

Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - RNA ; Aedes aegypti - Viral infections ; Aedes aegypti - Real Time PCR ; Aedes aegypti - virus ; Aedes aegypti - Transmission ; Aedes aegypti - Epidemiology ; Aedes aegypti - Immunology ; Aedes aegypti - Public health

Data de publicação: 2011