Anti-GQ1b-negative Miller Fisher syndrome after Campylobacter jejuni enteritis.
Autor(es): Lee Kyung Yeon
Resumo: Miller Fisher syndrome is a clinical variant of Guillain-Barré syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia. It results from an immune response to a cross-reactive antigen between GQ1b ganglioside in human neurons and lipo-oligosaccharides of certain bacteria, e.g., Campylobacter jejuni. Anti-GQ1b antibody is a powerful diagnostic marker for Miller Fisher syndrome. However, only a small number of anti-GQ1b-negative Miller Fisher syndrome cases are documented. A 13-year-old boy demonstrated typical clinical features of Miller Fisher syndrome 1 week after C. jejuni enteritis, but was anti-GQ1b and anti-GM1b antibody-negative.
Imprenta: Pediatric Neurology, v. 47, n. 3, p. 213-215, 2012
Identificador do objeto digital: 10.1016/j.pediatrneurol.2012.04.024
Descritores: Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2012
