Acute motor axonal neuropathy in a patient with prolonged CD4 depletion due to HIV: a local variant of macrophage activation syndrome?
Autor(es): Dardis Christopher
Resumo: Acute inflammatory demyelinating polyneuropathy or Guillain-Barré syndrome is well recognized as a presenting feature of human immunodeficiency virus (HIV) seroconversion and, to a lesser extent, as a complication of HIV infection, particularly immune reconstitution. Acute motor axonal neuropathy (AMAN) is much rarer in this setting. A case is presented of acute motor neuropathy, with features most consistent with AMAN in the setting of congenital HIV and prolonged non-compliance with antiretroviral treatment. The case throws new light on the pathogenesis of this condition. Macrophage activation is proposed as fundamental; the patient was predisposed by HIV as well as the use of granulocyte colony-stimulating factor and AMAN was then precipitated by a bacterial infection.
Imprenta: Oxford Medical Case Reports, v. 2015, n. 2, p. 200-202, 2015
Identificador do objeto digital: 10.1093/omcr/omv009
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Virus
Data de publicação: 2015
