Autor(es): Tada Masayoshi,Onodera Osamu,Kawachi Izumi,Hara Kenju,Sato Masahisa,Yoshino Hiide,Asano Atsuko,Soma Yoshiaki,Tsuji Shoji

Resumo: We report a 27-year-old man with Guillain-Barré syndrome (GBS) preceded by cytomegalovirus infection. He was admitted to our hospital because of distal dominant weakness and sensory disturbance 5 days after fever. Double filtration plasmapheresis (DFPP) was performed and clinical symptoms temporary but dramatically improved. However facial nerve palsy, difficulty in swallowing food, weakness, dysautonomia and respiratory failure rapidly progressed within 5 days after the onset. Repeated DFPP failed to improve his symptoms. Two months after the onset, he did not improve at all. On T1-weighted MRI, nerve roots were still enhanced with gadolinium, and CSF examination revealed 1,324 mg/dl of protein. These findings suggested us the existence of continuous inflammation on nerve roots. We gave steroid-pulse therapy. He dramatically improved after this treatment. We repeated steroid-pulse therapy for seven times. He was discharged without any major complication 6 months after the onset. Steroid-pulse therapy should be considered in GBS patients associated with CMV infection when other conventional treatments are ineffective.

Imprenta: No? To Shinkei = Brain and Nerve, v. 55, n. 7, p. 615-621, 2003

Identificador do objeto digital: 10.11477/mf.1406100514

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Inflammation ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2003

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