Urate oxidation in CSF and blood of patients with inflammatory disorders of the nervous system
Autor(es): Becker B F,Kastenbauer S,Ködel U,Kiesl D,Pfister H W
Resumo: Urate is largely excluded from the brain under non-inflammatory conditions (concentration gradient serum:CSF about 10:1), but increases markedly in Guillain-Barré Syndrome and bacterial meningitis. The oxidation product allantoin is normally not passively distributed between blood and cerebrospinal fluid (gradient 3:1) and increases 5-fold in CSF of patients with meningitis. Patients with multiple sclerosis had normal levels of urate and allantoin in blood and CSF.
Palavras-Chave: Allantoin; Blood-brain barrier; Meningitis; Multiple sclerosis; Urate
Imprenta: Nucleosides, Nucleotides & Nucleic acids, v. 23, n. 8-9, p. 1201-1204, 2004
Identificador do objeto digital: 10.1081/NCN-200027469
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Inflammation
Data de publicação: 2004
