Incidence of Guillain-Barré syndrome during a nationwide oral poliovirus vaccine campaign.
Autor(es): Kinnunen E.; Färkkilä M.; Hovi T.; Juntunen J.; Weckström P.
Resumo: Concomitant with a nationwide oral poliovirus vaccine (OPV) campaign in Finland in 1985, an unexpected rise in the number of patients hospitalized with the Guillain-Barré syndrome (GBS) occurred. An analysis based on hospital records covering a population of 1.17 million and 6 years revealed a significantly increased incidence of GBS coinciding with the OPV campaign. We carefully examined 10 cases with onset of GBS within 10 weeks after immunization. Only 4 patients could recall recent symptomatic infection, and we found no specific agent in these cases. Our study suggests that live-attenuated polioviruses may, like other infectious viruses, sometimes trigger the GBS.
Imprenta: Neurology, v. 39, n. 8, p. 1034-1036, 1989
Identificador do objeto digital: ?10.?1212/?WNL.?39.?8.?1034
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Vaccine ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health
Data de publicação: 1989
