Autor(es): Mendell J. R.; Kissel J. T.; Kennedy M. S.; Sahenk Z.; Grinvalsky H. T.; Pittman G. L.; Kyler R. S.; Roelofs R. I.; Whitaker J. N.; Bertorini T. E.

Resumo: A controlled randomized trial of plasma exchange combined with prednisone was compared with supportive care alone in patients with Guillain-Barré syndrome (GBS). There was no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of 2 British Medical Research Council grades of strength between the groups. The difference in our results and others that indicated a beneficial effect of plasma exchange may reflect an adverse effect of prednisone on recovery in GBS. Failure to find a benefit of plasma exchange in our patients also raises the possibility that GBS may be a heterogeneous disorder with humoral factors playing a role in some but not all patients.

Imprenta: Neurology, v. 35, n. 11, p. 1551-1555, 1985

Identificador do objeto digital: 10.1212/WNL.35.11.1551

Descritores: Guillain-Barre Syndrome - Public health

Data de publicação: 1985

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