Total ocular akinesis: Miller Fisher or Guillain-Barré syndrome?
Autor(es): Rajska Kinga,Ro?niecki Jacek,Loba Piotr,Zieli?ska Ma?gorzata,Broniarczyk-Loba Anna
Resumo: Total, bilateral ophthalmoplegia is very rare. More than 50% of cases are Miller Fisher (MFS) and Guillain-Barré (GBS) syndromes. There is a correlation of MFS with anti-GQ1b antibodies. High levels of GQ1b gangliosides are found in myelin sheathes of cranial nerves suplying the extraocular muscles. This may explain the association of anti-GQ1b antibodies with ophthalmoplegia. Anti-GQ1b were also found in cases of GBS accompanied by ophthalmoplegia, atypical MFS (MFS without ataxia), MFS/GBS overlap syndromes and Bickerstaff brainstem encephalitis. This has led some authors to classify them as 'anti-GQ1b syndromes'. In this article we describe a diagnostically difficult case of a patient with a very rare, total bilateral paralysis of all ocular muscles, accompanied by bilateral ptosis, diminished tendon reflexes of upper extremities, paresis and hypoesthesia of the left upper extremity.
Palavras-Chave: Ophthalmoplegia; Miller Fisher syndrome; Guillain-Barré syndrome
Imprenta: Neurologia i Neurochirurgia Polska, v. 45, n. 3, p. 297-300, 2011
Identificador do objeto digital: 10.1016/S0028-3843(14)60083-9
Descritores: Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Clinical examination
Data de publicação: 2011
