Hepatitis E virus and neurological injury.
Autor(es): Dalton Harry R; Kamar Nassim; van Eijk Jeroen J. J.; Mclean Brendan N; Cintas Pascal; Bendall Richard P.; Jacobs Bart C.
Resumo: Hepatitis E is hyperendemic in many developing countries in Asia and Africa, and is caused by hepatitis E virus (HEV) genotypes 1 and 2, which are spread via the faecal-oral route by contaminated water. Recent data show that HEV infection is also endemic in developed countries. In such geographical settings, hepatitis E is caused by HEV genotypes 3 and 4, and is mainly a porcine zoonosis. In a minority of cases, HEV causes acute and chronic hepatitis, but infection is commonly asymptomatic or unrecognized. HEV infection is associated with a number of extrahepatic manifestations, including a range of neurological injuries. To date, 91 cases of HEV-associated neurological injury - most commonly, Guillain-Barré syndrome, neuralgic amyotrophy, and encephalitis/myelitis - have been reported. Here, we review the reported cases, discuss possible pathogenic mechanisms, and present our perspectives on future directions and research questions.
Imprenta: Nature Reviews, v. 12, n. 2, 77-85, 2016
Identificador do objeto digital: 10.1038/nrneurol.2015.234
Descritores: Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2016
