Nerve ultrasound in miller fisher variant of Guillain-Barré syndrome.
Autor(es): Décard Bernhard F.; Fladt Joachim; Axer Hubertus; Fischer Dirk; Grimm Alexander
Resumo: Focal enlargement of the peripheral and spinal nerves, visualized using high-resolution ultrasound (HRUS), has been reported in early Guillain-Barré syndrome, but not in the Miller Fisher variant. We report the use of HRUS in 2 patients who presented with acute ataxic neuropathy, areflexia, and ophthalmoparesis. Ultrasound and/or nerve conduction studies (NCS) of peripheral nerves, the vagus, and spinal nerves C5/6 were performed at onset and 2 weeks after immunoglobulin therapy. Both patients fulfilled criteria for diagnosis of Miller Fisher syndrome (MFS). Laboratory findings revealed elevated ganglioside Q1b antibodies in both and an albuminolocytologic dissociation in 1 patient. In addition, 1 patient had NCS evidence for demyelinating neuropathy. However, ultrasound showed focal enlargement in the vagus, the spinal nerves, and/or in the peripheral nerves in both patients. After therapy, nerve enlargement decreased in parallel with clinical improvement. Spinal and/or peripheral nerve enlargement supports the diagnosis of MFS in early phases of the disease. Muscle Nerve 52: 1106-1110, 2015.
Palavras-Chave: Guillain-Barré syndrome, Miller-Fisher syndrome, demyelinating polyneuropathy, immune-mediated neuropathy, nerve ultrasonography
Imprenta: Muscle & Nerve, v. 52, n. 6, p. 1106-1110, 2015
Identificador do objeto digital: 10.1002/mus.24753
Descritores: Guillain-Barre Syndrome - Antibodies
Data de publicação: 2015
