Single-fiber electromyography shows terminal axon dysfunction in Miller Fisher syndrome: a case report
Autor(es): Lange Dale J,DeAngelis Tracy,Sivak Mark A
Resumo: We studied a patient with ophthalmoparesis and pupillary areflexia 2 weeks after a viral syndrome. Miller Fisher syndrome was suspected but GQ1b antibodies were not detected. To define neuromuscular involvement we performed electrodiagnostic studies. Single-fiber electromyography (SFEMG) in the extensor digitorum communis (EDC) showed abnormal jitter and axonal blocking, suggesting terminal axon dysfunction. Subsequent GQ1b antibody titers were elevated to borderline levels. Clinical symptoms gradually resolved. SFEMG may help characterize neuropathies associated with antibodies to neuronal ganglioside and identify involvement of the terminal axon and neuromuscular junction.
Palavras-Chave: Ganglioside antibodies; GQ1b antibody; Miller Fisher syndrome; Neuromuscular transmission; Peripheral neuropathy; Single-?ber EMG
Imprenta: Muscle & Nerve, v. 34, n. 2, p. 232-234, 2006
Identificador do objeto digital: 10.1002/mus.20544
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Transmission ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2006
