Widenings of the myelin lamellae in a typical Guillain-Barré syndrome
Autor(es): Vallat J M,Leboutet M J,Jauberteau M O,Tabaraud F,Couratier P,Akani F
Resumo: The so-called widening of the myelin lamellae" are thought to be specific ultrastructural features of peripheral nerve myelin in patients with peripheral neuropathy associated with a monoclonal dysglobulinemia of IgM type and antiglycolipid activity. We report here a case of Guillain-Barré syndrome with no evidence of serum monoclonal dysglobulinemia, presenting the typical widenings of the myelin lamellae in small-diameter myelinated fibers from a sural nerve biopsy. In view of the positive reaction with anti-C3d complement on direct immunofluorescence, an immunological mechanism may be involved in the widenings of the myelin lamellae."
Palavras-Chave: Guillain Barre syndrome; Monoclonal dysglobulinemia; Myelin lamellae; Complement mediated demyelination; Nerve biopsy
Imprenta: Muscle & Nerve, v. 17, n. 4, p. 378-380, 1994
Identificador do objeto digital: 10.1002/mus.880170403
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology
Data de publicação: 1994
