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Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome

Autor(es)Hughes R,Atkinson P,Coates P,Hall S,Leibowitz S
ResumoT-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barré syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.
ImprentaMuscle & Nerve, v. 15, n. 5, p. 568-575, 1992
Identificador do Objeto Digital10.1002/mus.880150506
DescritoresGuillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Genome ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Virus
Data de Publicação:1992