Autor(es): Sonnino Sandro,Chiricozzi Elena,Ciampa Maria Grazia,Mauri Laura,Prinetti Alessandro,Toffano Gino,Aureli Massimo

Resumo: In peripheral neuropathies, such as sensorimotor neuropathies, motor neuron diseases, or the Guillain-Barré syndrome, serum antibodies recognizing saccharide units, portion of oligosaccharides, or oligosaccharide chains, have been found. These antibodies are called anti-glycosphingolipid (GSL) or anti-ganglioside antibodies. However, the information on the aglycone carrying the hydrophilic oligosaccharide remains elusive. The absolute and unique association of GSL to the onset, development and symptomatology of the peripheral neuropathies could be misleading. Here, we report some thoughts on the matter.

Palavras-Chave: Glycoconjugates; Mimicry; Oligosaccharides; Peripheral neuropathies; Serum antibodies

Imprenta: Molecular Neurobiology, v. 54, n. 2, p. 1564-1567, 2016

Identificador do objeto digital: 10.1007/s12035-016-9775-8

Descritores: Guillain-Barre Syndrome - Antibodies

Data de publicação: 2016