Autor(es): Gross M L,Craggs R I,King R H,Thomas P K

Resumo: Experimental allergic neuritis (EAN) is a demyelinating disease of the peripheral nervous system that can be induced in laboratory animals. This disorder has been considered to show many similarities to acute inflammatory polyneuropathy (Guillain-Barré syndrome, GBS). Reports that plasma exchange may benefit patients with GBS prompted the investigation of the effect of plasma exchange in EAN. A controlled study was performed on New Zealand White rabbits. Sixteen animals were allocated to control or treatment groups at the onset of the disease. Clinical assessment on days 7 and 14 showed that treated animals were less severely affected neurologically (P = 0.05, day 7; P less than 0.001 day 14), with a commensurate reduction in the severity of the histological lesions in peripheral nerves.

Palavras-Chave: Experimental allergic neuritis; Plasma exchange; Demyelination

Imprenta: Journal of the Neurological Sciences, v. 61, n. 2, p. 149-160, 1983

Identificador do objeto digital: 10.1016/0022-510X(83)90001-1

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology

Data de publicação: 1983

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