Prominent sensory ataxia in Guillain-Barré syndrome associated with IgG anti-GD1b antibody.
Autor(es): Wicklein E. M.; Pfeiffer G.; Yuki N.; Hartard C.; Kunze K.
Resumo: Sensitization with GD1b has been shown to cause sensory neuropathy in rabbit. A patient with chronic sensory-dominant polyneuropathy who had IgM antibody specifically to GD1b has been reported previously. This report describes the first patient with acute demyelinating polyneuropathy with prominent sensory symptoms who had a high titer of serum IgG anti-GD1b antibody. The serum reacted with neither GM1 nor with other b-series gangliosides (GD2, GD3, GT1b and GQ1b). Improvement in symptoms was coincident with decrease in IgG anti-GD1b antibody titer after plasmapheresis. This case supports the experimental results in rabbit suggesting that anti-GD1b antibody functions in the development of sensory ataxia.
Imprenta: Journal of the Neurological Sciences, v. 151, n. 2, p. 227-229, 1997
Identificador do objeto digital: 10.1016/S0022-510X(97)00136-6
Descritores: Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1997
