Investigation of suspected Guillain-Barre syndrome in childhood: what is the role for gadolinium enhanced magnetic resonance imaging of the spine?
Autor(es): Smith Nicholas; Pereira John; Grattan-Smith Padraic
Resumo: To review the role of gadolinium-enhanced magnetic resonance imaging of the spine in the diagnosis of paediatric Guillain-Barre syndrome and compare it with nerve conduction studies and cerebrospinal fluid analysis. A retrospective review of investigations undertaken in children admitted to our institution with acute Guillain-Barre syndrome over a 10-year period was performed. Seven of eight children (88%) displayed post-gadolinium nerve root enhancement consistent with Guillain-Barre syndrome. This compared with supportive nerve conduction studies in 21/24 children (88%) and cerebrospinal fluid protein analysis consistent with the diagnosis in 16/20 children (80%). Nerve conduction studies are the recognised 'gold standard' technique for confirming a clinical diagnosis of Guillain-Barre syndrome. In this study, a high positive rate was demonstrated. While more experience is necessary, this study and the literature support gadolinium enhanced magnetic resonance imaging of the spine as a valuable, although not necessarily superior, investigation in the diagnosis of Guillain-Barre syndrome. It may be of particular benefit when specialist neurophysiology expertise is unavailable.
Palavras-Chave: Guillain-Barre syndrome, magnetic resonance imaging, neurophysiology, paediatric
Imprenta: Journal of Paediatrics and Child Health, v. 50, n. 10, 2014
Identificador do objeto digital: 10.1111/j.1440-1754.2010.01802.x
Descritores: Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Public health
Data de publicação: 2014
