Neuromuscular transmission is not impaired in axonal Guillain--Barré syndrome.
Autor(es): Kuwabara Satoshi; Kokubun N.; Misawa S.; Kanai K.; Isose S.; Shibuya K.; Noto Y.; Mori M.; Sekiguchi Y.; Nasu S.; Fujimaki Y.; Hirata K.; Yuki N
Resumo: Previous studies have shown that anti-GQ1b antibodies induce massive neuromuscular blocking. If anti-GM1 and -GD1a antibodies have similar effects on the neuromuscular junction (NMJ) in human limb muscles, this may explain selective motor involvement in axonal Guillain--Barré syndrome (GBS). Axonal-stimulating single-fibre electromyography was performed in the extensor digitorum communis muscle of 23 patients with GBS, including 13 with the axonal form whose sera had a high titre of serum IgG anti-GM1 or -GD1a antibodies. All patients with axonal or demyelinating GBS showed normal or near-normal jitter, and no blocking. In both axonal and demyelinating GBS, neuromuscular transmission is not impaired. Our results failed to support the hypothesis that anti-GM1 or -GD1a antibody affects the NMJ. In GBS, impulse transmission is presumably impaired in the motor nerve terminal axons proximal to the NMJ.
Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 82, n. 10, p. 1174-1177, 2011
Identificador do objeto digital: 10.1136/jnnp.2010.210708
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Transmission ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2011
