Autor(es): Pestronk A,Choksi R,Yee W C,Kornberg A J,Lopate G,Trotter J

Resumo: We tested for serum antibodies to glycosaminoglycans (GAGs), including heparan sulfate, in patients with Guillain-Barré syndrome (GBS) and other disorders. We used ELISA methods that optimize immunoglobulin binding to carbohydrate antigens to measure serum antibodies to heparan sulfate GAGs in GBS, and control neuromuscular and immune disorders. We found serum IgM or IgG antibodies to heparan sulfate GAGs in 34% of patients with GBS. Serum IgM binding to heparan sulfate GAGs was also found in some chronic demyelinating polyneuropathies, with the highest frequency (33%) in patients with IgM anti-MAG M-proteins. Antibodies to heparan sulfate GAGs were rare (1%) in control serums from patients with other disorders. This result is the first demonstration of high titer serum antibodies to a specific antigen in a substantial group of, and with some specificity for, patients with the classically described GBS syndrome of acute-onset, motor-sensory polyneuropathy with demyelinating features.

Palavras-Chave: Heparan sulfate; Proteoglycans; Glycosaminoglycans; Guillain-Barré syndrome; Humoral immunity; Antibodies; Myelin; Demyelination; Polyneuropathy

Imprenta: Journal of Neuroimmunology, v. 91, n. 1-2, p. 204-209, 1998

Identificador do objeto digital: 10.1016/S0165-5728(98)00182-9

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1998

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