HLA-DR antigens in Mexican patients with Guillain-Barré syndrome.
Autor(es): Gorodezky C.; Varela B.; Castro-Escobar L. E.; Chávez-Negrete A.; Escobar-Gutiérrez A.; Martínez-Mata J.
Resumo: The distribution of HLA-DR antigens was investigated in 38 Mexican Mestizo patients with Guillain-Barré syndrome (GBS) and in 100 healthy controls belonging to the same population. IgG, IgM, IgA, CH50, C3, C4 and the number of T and B lymphocytes were also evaluated in the patients. Only DR3 was significantly increased in the patients (Yates' chi 2 = 9.943, Pc = 0.014) and the relative risk for developing the disease was 3.49. These findings support the hypothesis that DR3 or a closely linked Ir gene may play some role in the susceptibility to GBS.
Imprenta: Journal of Neuroimmunology, v. 4, n. 1, p. 1-7, 1983
Identificador do objeto digital: 10.1016/0165-5728(83)90058-9
Descritores: Guillain-Barre Syndrome - Genome ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1983
