Autor(es): Kuijf Mark L.; Godschalk Peggy C. R.; Gilbert Michel.; Endtz Hubert P.; Tio-Gillen Anne P.; Ang C Wim.; van Doorn Pieter A.; Jacobs Bart C.

Resumo: The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies.

Imprenta: Journal of Neuroimmunology, v. 188, n. 1-2, n. 69-73, 2007

Identificador do objeto digital: 10.1016/j.jneuroim.2007.05.014

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2007