Polymorphisms of CD1 genes in chronic dysimmune neuropathies.
Autor(es): De Angelis Maria Vittoria; Notturno Francesca; Caporale Christina M.; Pace Marta; Uncini Antonino
Resumo: CD1 are MCH-like glycoproteins specialized in capturing and presenting glycolipid to T cells. Expression of CD1 molecules has been observed on endoneurial machrophages in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and vasculitis and polymorphisms of CID1A and CD1E genes have been associated with susceptibility to develop Guillain-Barré syndrome. In 46 patients with CIDP, in 13 patients with multifocal motor neuropathy and in 132 controls we genotyped exon 2 of CD1A and CD1E genes. We found no association between chronic dysimmune neuropathies, with or without anti-ganglioside antibodies, and polymorphisms of CD1A and CD1E genes.
Imprenta: Journal of Neuroimmunology, v. 186, n. 1-2, p. 161-163, 2007
Identificador do objeto digital: 10.1016/j.jneuroim.2007.03.001
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2007
