The sialic acid residue is a crucial component of C. jejuni lipooligosaccharide ganglioside mimicry in the induction Guillain-Barré syndrome
Autor(es): Xiang Shu Li,Zhong Min,Cai Fang Cheng,Deng Bing,Zhang Xiao Ping
Resumo: Guillain-Barré syndrome (GBS) is an autoimmune neuropathy that often follows C. jejuni infection. Sialic acid (N-acetylneuraminic acid, NANA) is a common constituent of lipooligosaccharide (LOS). The molecular mimicry between C. jejuni LOS and human peripheral nerve gangliosides is believed to play an important role in the pathogenesis of GBS. The neuB1 encodes NANA synthetase, required for the synthesis of NANA of C. jejuni LOS. A neuB1 mutant was constructed from a C. jejuni HS:19 wild strain. Mutant LOS could not bind the cholera toxin B subunit, failed to induce anti-GM1 antibodies, and did not cause pathological changes in the peripheral nerves. These data suggest that the NANA residue in LOS is a crucial epitope in realization of ganglioside molecular mimicry.
Palavras-Chave: Sialic acid residue; Campylobacter jejuni; Guillain-Barré syndrome; Molecular mimicry
Imprenta: Journal of Neuroimmunology, v. 174, n. 1-2, p. 126-132, 2006
Identificador do objeto digital: 10.1016/j.jneuroim.2006.02.009
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - RNA ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Molecular methods ; Guillain-Barre Syndrome - RT-PCR ; Guillain-Barre Syndrome - Molecular screening ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2006
