Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms
Autor(es): van Sorge Nina M,van der Pol W-Ludo,Jansen Marc D,Geleijns Karin P W,Kalmijn Sandra,Hughes Richard A C,Rees Jeremy H,Pritchard Jane,Vedeler Christian A,Myhr Kjell-Morten,Shaw Chris,van Schaik Ivo N,Wokke John H J,van Doorn Pieter A,Jacobs Bart C,van de Winkel Jan G J,van den Berg Leonard H
Resumo: Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.
Palavras-Chave: Guillain-Barré syndrome; Fc?R; Polymorphism
Imprenta: Journal of Neuroimmunology, v. 162, n. 1-2, p. 157-164, 2005
Identificador do objeto digital: 10.1016/j.jneuroim.2005.01.016
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Public health
Data de publicação: 2005
