Interleukin-10 promoter polymorphisms in patients with Guillain-Barré syndrome.
Autor(es): Myhr K-M.; Vågnes K. S.; Marøy T H.; Aarseth J. H.; Nyland H. I.; Vedeler C. A.
Resumo: Interleukin-10 (IL-10) may have both pro- and anti-inflammatory effects in Guillain-Barré syndrome (GBS). The distribution of polymorphisms in the IL-10 gene (-1082 (G/A), -819 (T/C) and -592 (A/C)) was analysed to determine whether they could influence disease susceptibility or clinical course in GBS. The -592 CC and -819 CC genotypes associated with increased IL-10 response were more frequent in the GBS patients than in the controls (P=0.027), but the polymorphisms did not influence the clinical course of the disease.
Imprenta: Journal of Neuroimmunology, v. 139, n. 1-2, p. 81-83, 2003
Identificador do objeto digital: 10.1016/S0165-5728(03)00133-4
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - DNA ; Guillain-Barre Syndrome - Genome ; Guillain-Barre Syndrome - Molecular Structure ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2003
