Phenotypic and functional properties of gamma delta T cells from patients with Guillain Barré syndrome.
Autor(es): Borsellino G.; Poccia F.; Placido R.; Tramonti D.; Mancino G.; Luchetti S.; Galgani S.; Bonetti B.; Bach S.; Cipriani B.; Brosnan C. F.; Battistini L.
Resumo: In this study we have examined the phenotypic and functional properties of circulating gamma delta T cells in patients with Guillain Barre syndrome (GBS), in normal healthy controls, and in patients with active multiple sclerosis (MS). Cells expressing the Vdelta2 T cell receptor showed elevated expression of the C-lectin receptor NKRP1A in both GBS and MS, suggestive of an activated state. However, in patients with GBS these cells failed to respond to pyrenil-pyrophosphate derivatives and Vdelta2 + T cell clones derived from these patients released lower levels of IFNgamma than Vdelta2 + clones derived from controls and MS patients. In contrast, in patients with GBS the Vdelta1 + subset was expanded, showed elevated expression of NKRPIA and Vdelta1 + clones derived from these patients secreted high levels of IL-4. Our findings of expanded NKRP-1A +, IL-4-producing Vdelta1 T cells in the GBS patients suggests the possibility that these cells are activated by the recognition of non-protein antigens in an MHC-unrestricted manner and contribute to the humoral response to glycolipids that is a hallmark of this disease.
Imprenta: Journal of Neuroimmunology, v. 102, n. 2, p. 199-207, 2000
Identificador do objeto digital: 10.1016/S0165-5728(99)00165-4
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines
Data de publicação: 2000
