HLA-antigens in Guillain-Barré syndrome.
Autor(es): Hafez M.; Nagaty M.; Al-Tonbary Y.; el-Shennawy F. A.; el-Mongui A.; el-Sallab S.; Attia S.
Resumo: A microlymphocytotoxicity test determined serologically the frequency of HLA antigens in 32 patients with Guillain-Barré syndrome and in 234 healthy control subjects. The results demonstrated significantly increased frequencies of A3 and B8. The relative risk was estimated to be 9.6 and 4.6 for the A3 and B8 antigens, respectively. Study of the gametic association revealed weak positive linkage disequilibrium and biological association. The results are discussed, and it is concluded that the aberrant genetic make-up of the patients makes them more susceptible to develop the syndrome after exposure to the environmental factor(s).
Imprenta: Journal of Neurogenetics, v. 2, n. 4, p. 285-290, 1985
Identificador do objeto digital: 10.3109/01677068509102324
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1985
