Incidence of human herpesvirus 6 in clinical samples from Swedish patients with demyelinating diseases.
Autor(es): Gustafsson Rasmus; Reitsma Renate; Strålfors Annelie; Lindholm Andreas; Press Rayomand; Fogdell-Hahn Anna
Resumo: Human herpesvirus 6 (HHV-6) has been reported to be associated with multiple sclerosis (MS) and Guillain-Barré syndrome (GBS). We analyzed cell-free HHV-6 DNA as an indication of active infection in the peripheral blood and cerebrospinal fluid (CSF) of Swedish patients with GBS, patients with chronic inflammatory demyelinating polyradiculoneuropathy, treatment-naïve patients with possible MS, interferon-? treated MS patients [with or without neutralizing antibodies (NAbs)], and control patients with headache. One of 14 GBS patients and one of eight patients with chronic inflammatory demyelinating polyradiculoneuropathy were positive for HHV-6 DNA in serum. Of the 27 treatment-naïve possible MS patients, two were positive in plasma and one in CSF. HHV-6 DNA was detected in the serum of three of 79 NAb+ patients and one of 102 NAb-interferon-? treated MS patients. HHV-6 DNA could not be detected in the plasma or CSF of any of the 33 controls, although the differences were not statistically significant. Our results do not suggest active HHV-6 infection to be a common phenomenon in any of the patient groups studied.
Palavras-Chave: CIDP, Guillain-Barré syndrome, HHV-6, IFN?, Multiple sclerosis, NAb
Imprenta: Journal of Microbiology, Immunology and Infection, v. 47, n. 5, p. 418-421, 2014
Identificador do objeto digital: 10.1016/j.jmii.2013.03.009
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - DNA ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2014
