PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome.
Autor(es): Godschalk Peggy C. R.; van Belkum Alex; van den Braak Nicole; van Netten Diana; Ang C Wim; Jacobs Bart C.; Gilbert Michel; Endtz Hubert P.
Resumo: Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy.
Imprenta: Journal of Clinical Microbiology, v. 45, n. 7, p. 2316-2320, 2007
Identificador do objeto digital: 10.1128/JCM.00203-07
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Infectious diseases ; Guillain-Barre Syndrome - Molecular methods ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2007
