Simultaneous development of acute disseminated encephalomyelitis and Guillain-Barré syndrome associated with H1N1 09 influenza vaccination
Autor(es): Hoshino Takao,Uchiyama Yumiko,Ito Eiichi,Osawa Shunsuke,Ohashi Takashi
Resumo: A 36-year-old man was admitted to our hospital because of urinary retention and muscle weakness affecting all 4 limbs after receiving a H1N1 09 influenza vaccination. Magnetic resonance imaging demonstrated multiple lesions in his brain and spinal cord. Furthermore, nerve conduction study showed acute sensorimotor neuropathy, and anti-GM2 antibodies were detected in his serum. Based on the temporal association and exclusion of alternative etiologies, we made a diagnosis of acute disseminated encephalomyelitis (ADEM) and Guillain-Barré syndrome (GBS). To our knowledge, this is the first case of co-morbid ADEM and GBS after influenza vaccination with positive anti-ganglioside antibodies.
Palavras-Chave: Acute disseminated encephalomyelitis; Anti-ganglioside antibody; GM2 ganglioside; GuillainBarré syndrome; Influenza vaccination
Imprenta: Internal Medicine (Tokyo, Japan), v. 51, n. 12, p. 1595-1598, 2012
Identificador do objeto digital: 10.2169/internalmedicine.51.7132
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Vaccine ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2012
