Autor(es): Corso J.; Lugert R.; Groß U.; Zautner A. E.

Resumo: Campylobacter spp. is the most common bacterial pathogen of gastroenteritis worldwide. Poultry is the main reservoir and consequently the main origin of infections for humans. As a consequence of a primary Campylobacter infection which typically manifests as diarrhea, there is an increased risk to suffer from post-infectious complications such as reactive arthritis, neuropathia, myositis or a Guillain-Barré Syndrome. Usually the verification of acute campylobacteriosis is made by stool culture. In contrast, post-infectious complications can be diagnosed by serological assays. Since most of them are based on whole cell lysates, an insufficient specificity results from cross-reactions between related species. Therefore, the use of recombinant antigens becomes more and more favorable. Campylobacter is able to secrete a number of proteins, which are amongst others necessary for cell invasion and therefore play a crucial role for virulence. One of these, Cj0069, has a similar specificity and sensitivity in the detection of anti-Campylobacter jejuni IgG compared to the well-established antigens OMP18 and P39. This makes it a suitable antigen for diagnosing C. jejuni post-infectious complications.

Palavras-Chave: Campylobacter jejuni, Cj0069, Guillain-Barré syndrome, OMP18, P39, arthritis, campylobacteriosis, serodiagnostics

Imprenta: European Journal of Microbiology & Immunology, v. 1, n. 1, p. 86-94, 2011

Identificador do objeto digital: 10.1556/EuJMI.1.2011.1.11

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Proteins

Data de publicação: 2011

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