Autor(es): Lim Jia Pei; Devaux Jérôme; Yuki Nobuhiro

Resumo: Guillain-Barré syndrome is classified into acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. Whereas autoantibodies to GM1 or GD1a induce the development of acute motor axonal neuropathy, pathogenic autoantibodies have yet to be identified in acute inflammatory demyelinating polyneuropathy and chronic inflammatory demyelinating polyneuropathy. This review highlights the importance of autoantibodies to peripheral nerve proteins in the physiopathology of acute and chronic inflammatory demyelinating polyneuropathies. Moreover, we listed up other potential antigens, which may become helpful biomarkers for acquired, dysimmune demyelinating neuropathies based on their critical functions during myelination and their implications in hereditary demyelinating neuropathies.

Palavras-Chave: Acute inflammatory demyelinating polyneuropathy, Autoantibody, Charcot-Marie-Tooth disease, Chronic inflammatory demyelinating polyneuropathy, Experimental autoimmune neuritis, Guillain-Barré syndrome

Imprenta: Autoimmunity Reviews, v. 13, n. 10, p. 1070-1078, 2014

Identificador do objeto digital: 10.1016/j.autrev.2014.08.005

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2014