Autor(es): Nyati Kishan K,Prasad Kashi N,Rizwan Arshi,Verma Avantika,Paliwal Vimal K

Resumo: To determine the expression of proinflammatory and anti-inflammatory cytokines in lymphocytes from the progressive and recovery phases of Guillain-Barré syndrome (GBS) after stimulation with Campylobacter jejuni outer membrane proteins. Case-control study. Sanjay Gandhi Postgraduate Institute of Medical Sciences. Sixty-five patients with GBS, 60 age- and sex-matched disease control individuals, and 68 healthy control individuals were included in the study. Lymphocytes from patients with GBS were stimulated with C jejuni outer membrane proteins, and the levels of different proinflammatory (T(H)1 [helper T cell, subtype 1]) and anti-inflammatory (T(H)2) cytokines were determined by reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay. In the progressive phase of the disease, the expressions of interferon ? (IFN-?), interleukin 1? (IL-1?), tumor necrosis factor (TNF), IL-6, IL-10, and the IFN-?:IL-4 ratio were significantly upregulated, but expressions of transforming growth factor (TGF)-?1 and IL-4 were lower in patients compared with disease and healthy controls. In contrast, the levels of IFN-?, IL-1?, TNF, IL-6, IL-10, and the IFN-?:IL-4 ratio were significantly lower, but TGF-?1 and IL-4 were upregulated in the recovery phase of GBS patients compared with controls. Upregulation of T(H)1 cytokines in the early disease course may be associated with immune-mediated disease progression due to neuronal inflammation, but upregulation of T(H)2 immune response during the later phase aids recovery from the disease.

Imprenta: Archives of Neurology, v. 68, n. 4, p. 445-452, 2011

Identificador do objeto digital: 10.1001/archneurol.2011.51

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Inflammation ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2011

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