Autor(es): Benatar M. G.; Eastman R. W.

Resumo: Neuromuscular disease is a common manifestation of human immunodeficiency virus infection and acquired immunodeficiency syndrome, but isolated and severe pathology confined to the motor roots or anterior horn cells are not a recognized clinical entity. To describe the novel clinical presentation of human immunodeficiency virus-related polyradiculopathy manifesting as isolated severe motor symptoms confined to the legs. A case series comprising 4 patients identified prospectively during a 6-month period. Patients were seen in the Department of Neurology, Groote Schuur Hospital, Cape Town, South Africa. This is an 800-bed teaching hospital, with approximately 5000 patients seen annually in the Department of Neurology. Patients were identified by their unique presentation with a severe isolated motor neuropathy in the lower limbs. All were Xhosa-speaking African women. Early human immunodeficiency virus infection may be associated with pure motor lumbosacral polyradiculopathy. It remains unclear whether this clinical syndrome should be regarded as a variant of the Guillain-Barre syndrome or whether it represents a unique disorder associated with early human immunodeficiency virus infection.

Imprenta: Archives of Neurology, v. 57, n. 7, p. 1034-1039, 2000

Identificador do objeto digital: 10.1001/archneur.57.7.1034

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Public health

Data de publicação: 2000

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