Immunoreactive myelin basic protein in cerebrospinal fluid of patients with peripheral neuropathies.
Autor(es): Cornblath D. R.; Griffin J. W.; Tennekoon G. I.
Resumo: The presence of myelin basic protein (MBP)-like material in cerebrospinal fluid (CSF) usually reflects breakdown of central nervous system myelin. Immunoreactive MBP levels were measured in 70 CSF specimens from 66 patients with a variety of peripheral neuropathies. Immunoreactive MBP was present in CSF in 70% (16 of 23) of patients with biopsy-proved chronic demyelinating polyneuropathies, whereas in neuropathies producing primarily axonal damage it was present in only 22% (5 of 23). In Guillain-Barré syndrome, 45% (9 of 20) of patients had immunoreactive MBP in the CSF. We conclude that MBP-like material is present in the CSF of most patients with longstanding demyelinating polyradiculoneuropathies and probably reflects detection of peripheral nervous system P1 protein.
Imprenta: Annals of Neurology, v. 20, n. 3, p. 370-372, 1986
Identificador do objeto digital: 10.1002/ana.410200319
Descritores: Guillain-Barre Syndrome - Proteins
Data de publicação: 1986
