Isolation of P2 protein--reactive T-cell lines from human blood.
Autor(es): Burns J.; Krasner L. J.; Rostami A.; Pleasure D.
Resumo: Human T-cell lines reactive with the peripheral nerve myelin protein, P2 protein, were isolated from the peripheral blood of 4 normal persons and 1 patient with Guillain-Barré syndrome. These predominantly helper phenotype T-cell lines were isolated and maintained in vitro by antigen stimulation followed by culture with interleukin 2. Myelin basic protein-reactive T cells were also isolated in parallel from the same subjects as antigen specificity controls. T cells recognizing myelin basic protein did not respond to P2 protein, nor did P2-reactive cells respond to myelin basic protein. These findings suggest that a potential for autoimmune reactivity with peripheral nervous system myelin antigens may exist for both normal persons and some patients with neurological disease.
Imprenta: Annals of Neurology, v. 19, n. 4, p. 391-393, 1986
Identificador do objeto digital: 10.1002/ana.410190416
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1986
