Autor(es)Klugkist H, Preuss S

ResumoTwo chronically alcohol-addicted patients, a 37-year old woman and a 22-year old man, developed a severe polyneuropathy after being treated with very high doses of disulfiram. In the first case there was a high-grade proximal tetraparesis, especially of the legs; in the other there was a similar largely motor, but predominantly distal, neuropathy. Electrophysiological tests established a pattern of axonal damage. Guillain-Barré syndrome was excluded by analysis of cerebrospinal fluid. Over a period of observation of 6 months and 2 1/2 years, respectively, the paresis continued even after disulfiram had been discontinued. 2 1/2 years later the electrophysiological changes were still present. As disulfiram treatment may cause severe side effects it is recommended that the lowest possible dosage by employed.

ImprentaDeutsche Medizinische Wochenschrift, v. 117, n. 34, p. 1278-1282, 1992

DescritoresGuillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis

Data de Publicação:1992